Synthesis Of Some Novel Pyrido Essay - 1556 Words

Synthesis of some novel Pyrido [2, 3-d] pyrimidine derivatives as potential antimicrobial and anticancer agents Mohamed Abd Ellatif Chemistry department, Faculty of science, Damanhour University, Egypt Email: mf_mohanad@yahoo.com mohamedabdellatif@dmu.edu.eg Abstract: The reactions of 2-amino-3-cyano-4.6-diarylpyridines with formic acid, glacial acetic acid, benzoyl chloride, formamide and acetamide afforded 5-(5-substitutedfuran-2-yl)-7-(4-substitutedphenyl)-3H-pyrido[2,3-d] Pyrimidin-4-one , 2-methyl-5-(5-substitutedfuran-2-yl)-7-(4- substituted phenyl)-3H-pyrido[2,3-d] pyrimidin-4-one, 5-(5-substitutedfuran-2-yl)-7-(4-substitutedphenyl)-2-phenyl-3H-pyrido[2,3-d] pyrimidin-4-one, 5-(5-substitutedfuran-2-yl)-7-(4-substituted phenyl)-pyrido[2,3-d] pyrimidin-4-ylamine, 5-(5-substitutedfuran-2-yl)-7-(4-substitutedphenyl)-2-methyl-pyrido[2,3-d] pyrimidin-4-ylamine, respectively. The newly synthesized heterocycles were characterized by elemental analysis, IR, 1H-NMR, 13C-NMR and mass spectral data. Compounds have been screened for their antibacterial, antifungal and anticancer activities. Key words: 5-substitutedfuran-2-yl, pyrimidine, Antimicrobial, Anticancer. Introduction: Pyrido[2,3-d]pyrimidines derivatives comprise a diverse and interesting group of drugs1,2. Pyrido[2,3-d]pyrimidines in general are extremely important for their biological activities. For example, some are antitumour3, antibacterial4, anticonvulsant5, antipyretic6, analgesic7, and CNS